<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with the Workiva Platform-->
<!--Copyright 2025 Workiva-->
<!--r:3d9f0020-6290-4637-a0b3-7fa7dcba36f4,g:8a537100-d588-486e-bca4-218bb8ad9c08-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://xerispharma.com/role/Cover" xlink:type="simple" xlink:href="xers-20250603.xsd#Cover"/>
  <link:presentationLink xlink:role="http://xerispharma.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_d45f9610-6631-405e-b41f-4c88058be894" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_DocumentType_d45f9610-6631-405e-b41f-4c88058be894" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_52e22241-c5ad-44ff-9c3f-9071986456d8" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_DocumentPeriodEndDate_52e22241-c5ad-44ff-9c3f-9071986456d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_84c89288-7288-40d4-81bd-ad76c0ca2b2e" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_EntityRegistrantName_84c89288-7288-40d4-81bd-ad76c0ca2b2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_fa4d2391-f8cf-4421-92f1-e233a811f63d" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_EntityIncorporationStateCountryCode_fa4d2391-f8cf-4421-92f1-e233a811f63d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_728c9b68-7656-4072-b6ca-8ac1b3557ebc" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_EntityFileNumber_728c9b68-7656-4072-b6ca-8ac1b3557ebc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_9e3e79a2-0a14-4397-97a6-72aca3f0ba21" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_EntityTaxIdentificationNumber_9e3e79a2-0a14-4397-97a6-72aca3f0ba21" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_922cc72f-2cfa-4beb-b2b7-0cb2640ed7f9" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_EntityAddressAddressLine1_922cc72f-2cfa-4beb-b2b7-0cb2640ed7f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_246cabe6-a4a6-4ef0-951f-176b1bfba923" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_EntityAddressAddressLine2_246cabe6-a4a6-4ef0-951f-176b1bfba923" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_e2231004-9dd8-4fe2-b534-e6bce9545ba3" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_EntityAddressCityOrTown_e2231004-9dd8-4fe2-b534-e6bce9545ba3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_181ecf86-32e9-4892-bbae-fe3521c5349b" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_EntityAddressStateOrProvince_181ecf86-32e9-4892-bbae-fe3521c5349b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_ce991b83-3e88-4652-a9f4-e5e5135ba6f0" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_EntityAddressPostalZipCode_ce991b83-3e88-4652-a9f4-e5e5135ba6f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_bf4b8c2a-1683-4e3a-b928-e7097b9a7acc" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_CityAreaCode_bf4b8c2a-1683-4e3a-b928-e7097b9a7acc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_e8a65c80-284f-4255-a54d-9297d839fe2e" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_LocalPhoneNumber_e8a65c80-284f-4255-a54d-9297d839fe2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_10ddc7be-c43b-4f99-ac26-b6e56347f807" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_WrittenCommunications_10ddc7be-c43b-4f99-ac26-b6e56347f807" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_8b6b062d-de19-4c0e-a1b1-777a7fb7a729" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_SolicitingMaterial_8b6b062d-de19-4c0e-a1b1-777a7fb7a729" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_d62ad0f1-f120-44d7-9632-a4845c49208f" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_PreCommencementTenderOffer_d62ad0f1-f120-44d7-9632-a4845c49208f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_eb4fa0bc-fe1d-48dc-bae2-dba3fcc2fd6c" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_eb4fa0bc-fe1d-48dc-bae2-dba3fcc2fd6c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_ea660f5c-b97c-4b7e-a30d-b091988902d2" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_Security12bTitle_ea660f5c-b97c-4b7e-a30d-b091988902d2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_09d9936e-cbc0-4a63-861a-a82e58f0b895" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_TradingSymbol_09d9936e-cbc0-4a63-861a-a82e58f0b895" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_caf26699-99dc-4058-8dc7-8f560e832ed4" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_SecurityExchangeName_caf26699-99dc-4058-8dc7-8f560e832ed4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_ae1a9436-9ba1-4fc9-aaf3-c4c64b669979" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_EntityEmergingGrowthCompany_ae1a9436-9ba1-4fc9-aaf3-c4c64b669979" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_27c383a3-d1bd-40ca-821a-670897c19175" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_AmendmentFlag_27c383a3-d1bd-40ca-821a-670897c19175" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_5a4f4ac6-898e-428e-9a6b-d6433e7b8444" xlink:href="https://xbrl.sec.gov/dei/2023/dei-2023.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_d7c8928c-b84e-4e78-8de8-6bb0c8eab2f5" xlink:to="loc_dei_EntityCentralIndexKey_5a4f4ac6-898e-428e-9a6b-d6433e7b8444" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
